Vaporization of perfluorocarbon droplets using optical irradiation

نویسندگان

  • Eric Strohm
  • Min Rui
  • Ivan Gorelikov
  • Naomi Matsuura
  • Michael Kolios
چکیده

Micron-sized liquid perfluorocarbon (PFC) droplets are currently being investigated as activatable agents for medical imaging and cancer therapy. After injection into the bloodstream, superheated PFC droplets can be vaporized to a gas phase for ultrasound imaging, or for cancer therapy via targeted drug delivery and vessel occlusion. Droplet vaporization has been previously demonstrated using acoustic methods. We propose using laser irradiation as a means to induce PFC droplet vaporization using a method we term optical droplet vaporization (ODV). In order to facilitate ODV of PFC droplets which have negligible absorption in the infrared spectrum, optical absorbing nanoparticles were incorporated into the droplet. In this study, micron-sized PFC droplets loaded with silica-coated lead sulfide (PbS) nanoparticles were evaluated using a 1064 nm laser and ultra-high frequency photoacoustic ultrasound (at 200 and 375 MHz). The photoacoustic response was proportional to nanoparticle loading and successful optical droplet vaporization of individual PFC droplets was confirmed using photoacoustic, acoustic, and optical measurements. A minimum laser fluence of 1.4 J/cm(2) was required to vaporize the droplets. The vaporization of PFC droplets via laser irradiation can lead to the activation of PFC agents in tissues previously not accessible using standard ultrasound-based techniques.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsions.

Perfluorocarbon droplets containing nanoparticles (NPs) have recently been investigated as theranostic and dual-mode contrast agents. These droplets can be vaporized via laser irradiation or used as photoacoustic contrast agents below the vaporization threshold. This study investigates the photoacoustic mechanism of NP-loaded droplets using photoacoustic frequencies between 100 and 1000 MHz, wh...

متن کامل

Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models

Perfluorocarbon (PFC) droplets were studied as new generation ultrasound contrast agents via acoustic or optical droplet vaporization (ADV or ODV). Little is known about the ODV irradiated vaporization mechanisms of PFC-microparticle complexs and the stability of the new bubbles produced. In this study, fluorescent perfluorohexane (PFH) poly(lactic-co-glycolic acid) (PLGA) particles were used a...

متن کامل

Parametric Study of Fuel Vapor Concentration Distribution Due to Vaporization of Fuel Droplets in Free Atmosphere

The growth of a two-phase cloud of a liquid fuel in a stagnant atmosphere is studied using computational fluid dynamic techniques. In order to predict the danger and hazard of such cloud in open atmosphere it is very important to determine the fuel concentration in the cloud, especially in the far field region from the fuel reservoir. The results show that with omission of droplets break up...

متن کامل

Abstract Submitted for the DFD09 Meeting of The American Physical Society Acoustic Droplet Vaporization through PDMS DAVID LI, STAN-

Submitted for the DFD09 Meeting of The American Physical Society Acoustic Droplet Vaporization through PDMS DAVID LI, STANLEY SAMUEL, J. BRIAN FOWLKES, JOSEPH BULL, The University of Michigan — Acoustic droplet vaporization (ADV) involves the generation of bubbles from albumin-encapsulated perfluorocarbon (PFC) droplets that have been insonated with high intensity ultrasound (US). Gas embolothe...

متن کامل

In vivo microscopy of targeted vessel occlusion employing acoustic droplet vaporization.

OBJECTIVE Embolotherapy is a potential means to treat a variety of cancers. Our approach-gas embolotherapy-introduces the droplets upstream from the tumor and then acoustically activates them to form bubbles for occlusion-a process known as ADV. We wanted to provide the first optical documentation of ADV, lodged bubbles, or vessel occlusion in vivo. METHODS We used the rat cremaster muscle fo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2011